Effect of Rodent Control Program on Incidence of Zoonotic Cutaneous Leishmaniasis, Iran

We report the effect of a rodent control program on the incidence of zoonotic cutaneous leishmaniasis in an endemic region of Iran. A 1-year interruption in rodent control led to 2 years of increased incidence of zoonotic cutaneous leishmaniasis. Restarting rodent control led to a decline of zoonotic cutaneous leishmaniasis.

rodent nests in early April (4).Once a month in April, May, June, and September, rodent nest baiting is performed by using a mixture of wheat with 2.5% zinc phosphide (4) (Appendix Figure 3).The rodent nest baiting is conducted in a 500-m circle around houses within the intervention area (4).
The RCP was completely ceased during the first year of the COVID-19 pandemic in Jahrom county because of a lack of equipment and personnel.The program was resumed routinely in early April 2021 (5).The outcome of the 1-year interruption in the RCP was a mild increase in the incidence of ZCL in 2020 and a high increase in ZCL in 2021 (Appendix Figure 2).Incidence rates for the period before the pandemic were stable: 103.7 cases/100,000 population in 2016, 95.1 cases/100,000 population in 2017, 99.7 cases/100,000 population in 2018, and 99.6 cases/100,000 population in 2019 (Figure).After the RCP stopped because of the COVID-19 pandemic, ZCL incidence rates increased to 129.4 cases/100,000 population in 2020 and 321.5 cases/100,000 population in 2021, (  2).
Jahrom county has an agricultural environment that provides suitable conditions for both the rodent reservoirs and sand fly vectors of L. major.Although different studies have demonstrated the effectiveness of the RCP for control of ZCL (4,6,7), little is known about the impact of a short-term interruption of the RCP on the incidence of ZCL in an endemic region.The unplanned interruption of the RCP in Jahrom county because of the COVID-19 pandemic gave us the opportunity to evaluate the impact of the RCP on the incidence of ZCL in an endemic area.Although the RCP was paused for only 1 year and resumed routinely in early April The emergence of COVID-19 has a considerable influence on the burden of noncommunicable and communicable diseases throughout the world and in Iran (8,9).In Brazil, the COVID-19 pandemic seems to have contributed to an increase in the incidence of tegumentary leishmaniasis in 2020 (10).A decreasing incidence of CL was reported in an endemic region in western Iran during the COVID-19 pandemic (2020-2021), possibly because of the disruption of CL diagnosis and treatment follow-up (11).

Conclusions
Our study showed a 1-year interruption to the RCP contributed to 2 years of increased incidence of ZCL in an endemic region of Iran.Restarting the RCP led to the decline of ZCL after 2 years of program activity.However, additional factors, such as environmental conditions (e.g., climate conditions and rainfall) that have an influence on vector and reservoir propagation, and diagnosis and treatment follow-up, could influence the incidence of ZCL (12,13).In the absence of a vaccine for ZCL, an RCP is an effective strategy for ZCL control in endemic regions.
This study was supported by Jahrom University of Medical Sciences, Jahrom, Iran (grant nos.402000084 and 99000159) and the National Institute for Medical Research Development (grant no.978507).

About the Author
Dr. Abdoli is associate professor of medical parasitology at Jahrom University of Medical Sciences.His research interests include parasitology and zoonotic infections.D ermatophilus congolensis From the Greek derma (skin) + philos (loving), Der- matophilus congolensis is a Gram-positive, aerobic actinomycete, and facultatively anaerobic bacteria.D. congolensis infects the epidermis and produces exudative dermatitis termed dermatophilosis that was previously known as rain rot, rain scald, streptotrichosis, and mycotic dermatitis.
In 1915, René Van Saceghem, a Belgian military veterinarian stationed at a veterinary laboratory in the former Belgian Congo (thus, the species name congolensis), reported D. congolensis from exudative dermatitis in cattle.Local breeders and veterinarians had observed the disease since 1910, but the causal agent was not identified.
Dermatophilosis affects animals, mainly cattle, and more rarely humans.Outbreaks of D. congolensis infection have severe economic implications in the livestock and leather industries.

Sources
Amir Abdoli, Samaneh Mazaherifar, Kavous Solhjoo, Mohsen Farhang Zargar, Hayedeh Parvin Jahromi, Ali Taghipour, Mohammad Darayesh, Milad Badri, Majid Pirestani, Shahab Falahi, Azra Kenarkoohi 2021, a slight increase in the incidence of ZCL was observed (129.4 cases/100,000 population in 2020) and a marked increase in ZCL the following year (321.5 cases/100,000 population in 2021).However, because of the COVID-19 lockdown, the diagnosis and treatment of CL patients were interrupted during the first year of the pandemic (2020), so those factors could be involved in the increase in the incidence of ZCL in 2020 and 2021.Of interest, a sharp decline in the incidence rates was observed in 2022 and 2023 (72.1 cases/100,000 population in 2022 and 19.2 cases/100,000 population in 2023).However, comparing the incidences of ZCL in 2022 and 2023 with the incidences before 2020 has shown that factors other than the RCP could be contributing to the decline of ZCL because the incidence rates of 2022 and 2023 were much lower than the incidence rates before 2020 (Table; Figure; Appendix Figure 2).Other factors, such as climate conditions and rainfall, which are involved in the propagations of rodents and sand flies, could also contribute to the decline of ZCL observed in 2022 and 2023.